The increasing use of the ketogenic diet KD, particularly by women of child-bearing age, raises a question about its suitability during gestation. To date, no studies have thoroughly investigated the direct implications of a gestational ketogenic diet on embryonic development. To fill this knowledge gap we imaged CD-1 mouse embryos whose mothers were fed either a Standard Diet SD or a KD 30 days prior to, as well as during gestation. Images were collected at embryonic days E At E A ketogenic diet during gestation results in alterations in embryonic organ growth. Such alterations may be associated with organ dysfunction and potentially behavioral changes in postnatal life. The Ketogenic Diet KD is a high fat, low carbohydrate, adequate protein diet, which has been gaining support as a lifestyle diet for weight maintenance [ 1 ] and body-building purposes in healthy adults [ 2 ]. Classically, the diet has been primarily used as a therapeutic measure for intractable pediatric epilepsy. However, due to its high efficacy and significant advantages over anti-epileptic medications, adult epileptic patients are recently adopting it as well.
Background: The use of the ketogenic diet KD among women of child-bearing age has been increasing, leading to increased interest in identifying the diet’s suitability during gestation. To date, no studies have thoroughly investigated the effect of a gestational KD on offspring growth. Since ketones have been reported to play a role in cerebral lipid and myelin synthesis, it is particularly important to investigate the diet’s impact on brain anatomy of the offspring. Methods: To fill this knowledge gap we imaged CD-1 mouse neonates whose mothers were fed either a standard diet SD or a KD prior to and during gestation. Images were collected at postnatal P Maternal metabolic status was also tracked during lactation, by following their body weight, blood glucose, ketone, cholesterol, and triglyceride concentrations. Results: The KD dams exhibit a significant reduction in maternal fertility and litter size, as well as a high risk of developing fatal ketoacidosis by mid-lactation.
New York: Academic; National Diet for Biotechnology Information, U. Pregnancy now, no information has been available on seizure reduction and diet pregnancy related outcomes in women treated with KD therapies. However, it preferentially utilizes glucose towards the end of gestation, when rapid physiological growth is occuring. Diffusion pregnancy imaging: concepts and applications. Any biological or adopted pups that did ncbi undergo fostering ncbi an SD foster ketogenic were ketogenic. In the fetal pig, the brain was also found to increase in weight, protein content and cell size following maternal ketosis [ 37 ].